https://rasayely-journals.com/index.php/hpbci <p>HPB Cancer International (HPBCI) is an open-access peer-reviewed journal committed to publishing research papers, review articles, clinical studies, case reports, and short communications on the epidemiology, diagnosis, prognosis, and management of cancers in the hepatobiliary or pancreatic system.</p> <p>HPBCI aims to publish high-quality publications by applying a thorough and accurate editorial workflow. The editorial workflow is managed by the editorial board which contains a panel of experts in Hepato-Pancreato-Biliary Cancers.</p> Rasayely en-US HPB Cancer International 2974-3249 <p>Authors retain the copyright of their manuscripts, and all Open Access articles are distributed under the terms of the <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noopener">Creative Commons Attribution License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.</p> https://rasayely-journals.com/index.php/hpbci/article/view/107 <p>Hepatocellular carcinoma (HCC) is the fourth most common malignancy and the third leading cause of cancer-related deaths among males in Macao population. Despite active preventative and screening measures, a majority of HCC patients present with advanced, unresectable disease. The treatment landscape for advanced HCC (aHCC) is rapidly evolving with the availability of novel agents. However, real-world evidence on the management of aHCC remains sparse, especially across different geographic areas, and there is currently no consensus guideline on optimal treatment sequence. In this report, we present the case of a male patient with large, multifocal aHCC, developing a complete pathological response (pCR) after a multidisciplinary onco-surgical approach.</p> Ingrid Karmane Sumou Cheng Vai Hui Lai Fong Kok José Costa-Maia Copyright (c) 2024 Ingrid Karmane Sumou, Cheng Vai Hui, Lai Fong Kok, José Costa-Maia https://creativecommons.org/licenses/by/4.0 2024-05-09 2024-05-09 2 1 1–4 1–4 https://rasayely-journals.com/index.php/hpbci/article/view/114 <p>Commonly known as the Whipple’s procedure, a pancreaticoduodenectomy is a surgical operation for aggressive pancreatic cancer with a 10% five-year survival rate, which can potentially provide clearance or control of patient symptomatology. In pancreaticoduodenectomy, injury to major vascular structures such as the hepatic artery can occur, with subsequent high morbidity and mortality related to hepatic complications. This paper describes two cases where damage to major vasculature occurred during a pancreaticoduodenectomy, and portal vein arterialization (PVA) was used as a revascularization option. The first case describes a 69-year-old female who sustained an injury to the common hepatic artery during the procedure. Initial revascularization via direct primary end-to-end anastomosis and a saphenous vein graft were unsuccessful, so PVA was established with success. The second case describes a 52-year-old male who had a segment of the right hepatic artery resected en bloc with the tumor. Initial attempts at end-to-end arterial reconstruction proved futile, and intraoperatively ischemic changes were noted by the surgeon who opted to perform PVA to establish arterial flow. Although multiple options for revascularization of the hepatic artery exist, here we describe two cases where portal vein arterialization is used as a straightforward and successful salvage technique, especially when other options have proved futile.</p> Madeleine Kelly Pranavan Palamuthusingam Peter Lodge Copyright (c) 2024 Madeleine Kelly, Pranavan Palamuthusingam, Peter Lodge https://creativecommons.org/licenses/by/4.0 2024-05-31 2024-05-31 2 1 5–8 5–8